Expression and function of gonadotropin-releasing hormone (GnRH) receptor in human olfactory GnRH-secreting neurons: an autocrine GnRH loop underlies …
Olfactory neurons and gonadotropin-releasing hormone (GnRH) neurons share a common
origin during organogenesis. Kallmann's syndrome, clinically characterized by anosmia and
hypogonadotropic hypogonadism, is due to an abnormality in the migration of olfactory and
GnRH neurons. We recently characterized the human FNC-B4 cell line, which retains
properties present in vivo in both olfactory and GnRH neurons. In this study, we found that
FNC-B4 neurons expressed GnRH receptor and responded to GnRH with time-and dose …
origin during organogenesis. Kallmann's syndrome, clinically characterized by anosmia and
hypogonadotropic hypogonadism, is due to an abnormality in the migration of olfactory and
GnRH neurons. We recently characterized the human FNC-B4 cell line, which retains
properties present in vivo in both olfactory and GnRH neurons. In this study, we found that
FNC-B4 neurons expressed GnRH receptor and responded to GnRH with time-and dose …
