The purpose of the study was to examine the effect of lentivirus-mediated IL-10 gene therapy
to target lung allograft rejection in a mouse orthotopic left lung transplantation model. IL-10
may regulate posttransplant immunity mediated by IL-17. Lentivirus-mediated trans-airway
luciferase gene transfer to the donor lung resulted in persistent luciferase activity up to 6
months posttransplant in the isograft (B6 to B6); luciferase activity decreased in minor-
mismatched allograft lungs (B10 to B6) in association with moderate rejection. Fully MHC …