Role of T follicular helper and T follicular regulatory cells in antibody-mediated rejection: new therapeutic targets?
H Zhang, PT Sage - Current opinion in organ transplantation, 2022 - journals.lww.com
H Zhang, PT Sage
Current opinion in organ transplantation, 2022•journals.lww.comAbMR is still a substantial clinical problem that restricts long-term survival after solid organ
transplantation. Growing evidence has demonstrated a pivotal role for Tfh and Tfr cells in
controlling AbMR. In addition to providing an early indication of rejection as a biomarker,
targeting Tfh and Tfr cells as a therapeutic strategy offers new hope for alleviating AbMR.
transplantation. Growing evidence has demonstrated a pivotal role for Tfh and Tfr cells in
controlling AbMR. In addition to providing an early indication of rejection as a biomarker,
targeting Tfh and Tfr cells as a therapeutic strategy offers new hope for alleviating AbMR.
Summary
AbMR is still a substantial clinical problem that restricts long-term survival after solid organ transplantation. Growing evidence has demonstrated a pivotal role for Tfh and Tfr cells in controlling AbMR. In addition to providing an early indication of rejection as a biomarker, targeting Tfh and Tfr cells as a therapeutic strategy offers new hope for alleviating AbMR.
Lippincott Williams & Wilkins