De novo purine synthesis in skeletal muscle

S Brosh, P Boer, E Zoref-Shani, O Sperling - Biochimica et Biophysica Acta …, 1982 - Elsevier
S Brosh, P Boer, E Zoref-Shani, O Sperling
Biochimica et Biophysica Acta (BBA)-General Subjects, 1982Elsevier
Myoblast and primary muscle cultures from rat were found to contain the complete pathway
of de novo purine nucleotide synthesis. Quantitative assessment of the pathway in skeletal
muscle in mice in vivo, revealed a more intensive purine production in muscle than in liver.
Skeletal muscle is thus a major site of de novo purine production in the mammalian body.
Abstract
Myoblast and primary muscle cultures from rat were found to contain the complete pathway of de novo purine nucleotide synthesis. Quantitative assessment of the pathway in skeletal muscle in mice in vivo, revealed a more intensive purine production in muscle than in liver. Skeletal muscle is thus a major site of de novo purine production in the mammalian body.
Elsevier